Development of mask-cream technology with herbal substances for the androgenic alopecia treatment

• Main Authors: Maryana Fedorovska, Natalia Polovko, Natalia Leochko
• Format: Article
• Language: English
• Published: PC Technology Center 2017-06-01
• Series: ScienceRise: Pharmaceutical Science
• Subjects: крем-маска; андрогенна алопеція; екстракт пальми сабаль; настойка софори японської; технологія
• Online Access: http://journals.uran.ua/sr_pharm/article/view/103544

Aim. The aim of the study was to develop a rational technology of mask-cream containing Sabal palm extract and Sophora japonica tincture applied for prevention and tratment of androgenic alopecia. Methods. Pharmaco-technological, physico-chemical, rheological and microscopy methods were used. Results. Using microscopy studies aimed to determine the dispersion of the oil phase particles of the mask-cream it was found that the largest percentage of emulsion drops of up to 4 μm, in particular 74.4 %, was in the sample produced by reverse emulsion method. The given sample was characterized by the structural viscosity value at 20 ºС and 20 rpm – 9060 mPa·Sec, which was close to the carrier base viscosity. The increase of homogenization speed and period sufficiently reduced the average size of the dispersed phase only to a certain point, therefore, optimal parameters for the cream-mask homogenization were chosen – 2000 rpm, within 20 minutes. The active substances (Sabal palm extract, Sophora japonica tincture) and the excipients (preservatives, thickener, flavor) were put into the base gradually, concerning their physical and chemical properties. Conclusion. Technological parameters of the mask-cream preparation using emulsion base were determined: reverse emulsion method, homogenization parameters – 20 minutes at 2000 rpm. Technological scheme for production of the mask-cream containing Sabal palm extract and Sophora japonica tincture was developed