Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin

Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin

CAPNS1 is essential for stability and function of the ubiquitous calcium-dependent proteases micro- and milli-calpain. Upon inhibition of the endoplasmic reticulum Ca2+ ATPase by 100 nM thapsigargin, both micro-calpain and autophagy are activated in human U2OS osteosarcoma cells in a CAPNS1-dependen...

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Bibliographic Details
Main Authors: Elena Marcassa, Marzia Raimondi, Tahira Anwar, Eeva-Liisa Eskelinen, Michael P. Myers, Gianluca Triolo, Claudio Schneider, Francesca Demarchi
Format: Article
Language:English
Published: The Company of Biologists 2017-05-01
Series:Biology Open
Subjects:
Calpain
CAPNS1
Bif-1
Endophilin B1
Autophagy
Thapsigargin
Online Access:http://bio.biologists.org/content/6/5/551

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