Structure of human RNA polymerase III

The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms...

Full description

Bibliographic Details
Main Authors:	Ewan Phillip Ramsay, Guillermo Abascal-Palacios, Julia L. Daiß, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel, Alessandro Vannini
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20262-5

id	doaj-addf731bc84249d4a4c0c47a0f5420f5
record_format	Article
spelling	doaj-addf731bc84249d4a4c0c47a0f5420f52021-01-31T13:48:36ZengNature Publishing GroupNature Communications2041-17232020-12-0111111210.1038/s41467-020-20262-5Structure of human RNA polymerase IIIEwan Phillip Ramsay0Guillermo Abascal-Palacios1Julia L. Daiß2Helen King3Jerome Gouge4Michael Pilsl5Fabienne Beuron6Edward Morris7Philip Gunkel8Christoph Engel9Alessandro Vannini10Division of Structural Biology, The Institute of Cancer ResearchDivision of Structural Biology, The Institute of Cancer ResearchRegensburg Center for Biochemistry, University of RegensburgDivision of Structural Biology, The Institute of Cancer ResearchDivision of Structural Biology, The Institute of Cancer ResearchRegensburg Center for Biochemistry, University of RegensburgDivision of Structural Biology, The Institute of Cancer ResearchDivision of Structural Biology, The Institute of Cancer ResearchMax Planck Institute for Biophysical Chemistry, Research Group Nuclear ArchitectureRegensburg Center for Biochemistry, University of RegensburgDivision of Structural Biology, The Institute of Cancer ResearchThe eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.https://doi.org/10.1038/s41467-020-20262-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ewan Phillip Ramsay Guillermo Abascal-Palacios Julia L. Daiß Helen King Jerome Gouge Michael Pilsl Fabienne Beuron Edward Morris Philip Gunkel Christoph Engel Alessandro Vannini
spellingShingle	Ewan Phillip Ramsay Guillermo Abascal-Palacios Julia L. Daiß Helen King Jerome Gouge Michael Pilsl Fabienne Beuron Edward Morris Philip Gunkel Christoph Engel Alessandro Vannini Structure of human RNA polymerase III Nature Communications
author_facet	Ewan Phillip Ramsay Guillermo Abascal-Palacios Julia L. Daiß Helen King Jerome Gouge Michael Pilsl Fabienne Beuron Edward Morris Philip Gunkel Christoph Engel Alessandro Vannini
author_sort	Ewan Phillip Ramsay
title	Structure of human RNA polymerase III
title_short	Structure of human RNA polymerase III
title_full	Structure of human RNA polymerase III
title_fullStr	Structure of human RNA polymerase III
title_full_unstemmed	Structure of human RNA polymerase III
title_sort	structure of human rna polymerase iii
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-12-01
description	The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.
url	https://doi.org/10.1038/s41467-020-20262-5
work_keys_str_mv	AT ewanphillipramsay structureofhumanrnapolymeraseiii AT guillermoabascalpalacios structureofhumanrnapolymeraseiii AT julialdaiß structureofhumanrnapolymeraseiii AT helenking structureofhumanrnapolymeraseiii AT jeromegouge structureofhumanrnapolymeraseiii AT michaelpilsl structureofhumanrnapolymeraseiii AT fabiennebeuron structureofhumanrnapolymeraseiii AT edwardmorris structureofhumanrnapolymeraseiii AT philipgunkel structureofhumanrnapolymeraseiii AT christophengel structureofhumanrnapolymeraseiii AT alessandrovannini structureofhumanrnapolymeraseiii
_version_	1724316985977733120

Structure of human RNA polymerase III

Similar Items