Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on <it>de novo </it>cholesterol synthesis

Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on <it>de novo </it>cholesterol synthesis

<p>Abstract</p> <p>Background</p> <p>Previous observations demonstrate that <it>Cftr</it>-null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, increased <it>de novo </it>synthesis, a...

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Bibliographic Details
Main Authors: Sonawane Nitin D, Previs Stephen F, Jiang Dechen, Ruddy Jennifer, Manson Mary E, West Richard H, Fang Danjun, Burgess James D, Kelley Thomas J
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Respiratory Research
Online Access:http://respiratory-research.com/content/11/1/61

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