Immunotherapy and Immune Evasion in Prostate Cancer

• Main Authors: Archana Thakur, Ulka Vaishampayan, Lawrence G. Lum
• Format: Article
• Language: English
• Published: MDPI AG 2013-05-01
• Series: Cancers
• Subjects: prostate cancer; immunotherapy; vaccine; castrate resistant prostate cancer; bispecific antibody
• Online Access: http://www.mdpi.com/2072-6694/5/2/569

Metastatic prostate cancer remains to this day a terminal disease. Prostatectomy and radiotherapy are effective for organ-confined diseases, but treatment for locally advanced and metastatic cancer remains challenging. Although advanced prostate cancers treated with androgen deprivation therapy achieves debulking of disease, responses are transient with subsequent development of castration-resistant and metastatic disease. Since prostate cancer is typically a slowly progressing disease, use of immune-based therapies offers an advantage to target advanced tumors and to induce antitumor immunity. This review will discuss the clinical merits of various vaccines and immunotherapies in castrate resistant prostate cancer and challenges to this evolving field of immune-based therapies.