Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis

Abstract Background Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, skeletal muscle molecular pathways may contribute. The purpose of this study w...

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Bibliographic Details
Main Authors: Brian J. Andonian, Andrew Johannemann, Monica J. Hubal, David M. Pober, Alec Koss, William E. Kraus, David B. Bartlett, Kim M. Huffman
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Skeletal muscle
Cardiorespiratory fitness
Metabolism
Gene expression
Disease activity
Online Access:https://doi.org/10.1186/s13075-021-02570-3

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