Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

Abstract Background Uncontrolled microglial activation contributes to the pathogenesis of various neurodegenerative diseases. Previous studies have shown that proinflammatory microglia are powered by glycolysis, which relays on high levels of glucose uptake. This study aimed to understand how glucos...

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Bibliographic Details
Main Authors: Luxi Wang, Sofia Pavlou, Xuan Du, Mohajeet Bhuckory, Heping Xu, Mei Chen
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Neurodegeneration
Subjects:
Neuroinflammation
Microglia
Glucose metabolism
Retinal degeneration
Online Access:http://link.springer.com/article/10.1186/s13024-019-0305-9

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