Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery

Two types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible γ-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles. The nanoparticles, together with human serum albumin (HSA) serving as a model for a protein-type dru...

Full description

Bibliographic Details
Main Authors:	Shubhra Quazi T.H., Macková Hana, Horák Daniel, Fodor-Kardos Andrea, Tóth Judit, Gyenis János, Feczkó Tivadar
Format:	Article
Language:	English
Published:	De Gruyter 2013-08-01
Series:	e-Polymers
Online Access:	https://doi.org/10.1515/epoly.2013.2013.1.310

id	doaj-add718e266504a708053f887e6e09eb3
record_format	Article
spelling	doaj-add718e266504a708053f887e6e09eb32021-09-05T20:44:54ZengDe Gruytere-Polymers1618-72292013-08-012013131031810.1515/epoly.2013.2013.1.310Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug deliveryShubhra Quazi T.H.0Macková Hana1Horák Daniel2Fodor-Kardos Andrea3Tóth Judit4Gyenis János5Feczkó Tivadar6Research Institute of Chemical and Process Engineering, Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, HungaryInstitute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech RepublicInstitute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech RepublicResearch Institute of Chemical and Process Engineering, Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, HungaryResearch Institute of Chemical and Process Engineering, Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, HungaryResearch Institute of Chemical and Process Engineering, Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, HungaryResearch Institute of Chemical and Process Engineering, Doctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, HungaryTwo types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible γ-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles. The nanoparticles, together with human serum albumin (HSA) serving as a model for a protein-type drug, were then incorporated in poly(lactide-co-glycolide) (PLGA) particles using double emulsion solvent evaporation technique. Morphology, size and particle size distribution of the resulting particles was analyzed by electron microscopy and dynamic light scattering. Iron oxide and HSA encapsulating efficiency was determined by Prussian Blue staining and micro-BCA assay, respectively.https://doi.org/10.1515/epoly.2013.2013.1.310
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shubhra Quazi T.H. Macková Hana Horák Daniel Fodor-Kardos Andrea Tóth Judit Gyenis János Feczkó Tivadar
spellingShingle	Shubhra Quazi T.H. Macková Hana Horák Daniel Fodor-Kardos Andrea Tóth Judit Gyenis János Feczkó Tivadar Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery e-Polymers
author_facet	Shubhra Quazi T.H. Macková Hana Horák Daniel Fodor-Kardos Andrea Tóth Judit Gyenis János Feczkó Tivadar
author_sort	Shubhra Quazi T.H.
title	Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery
title_short	Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery
title_full	Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery
title_fullStr	Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery
title_full_unstemmed	Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery
title_sort	encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery
publisher	De Gruyter
series	e-Polymers
issn	1618-7229
publishDate	2013-08-01
description	Two types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible γ-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles. The nanoparticles, together with human serum albumin (HSA) serving as a model for a protein-type drug, were then incorporated in poly(lactide-co-glycolide) (PLGA) particles using double emulsion solvent evaporation technique. Morphology, size and particle size distribution of the resulting particles was analyzed by electron microscopy and dynamic light scattering. Iron oxide and HSA encapsulating efficiency was determined by Prussian Blue staining and micro-BCA assay, respectively.
url	https://doi.org/10.1515/epoly.2013.2013.1.310
work_keys_str_mv	AT shubhraquazith encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery AT mackovahana encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery AT horakdaniel encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery AT fodorkardosandrea encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery AT tothjudit encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery AT gyenisjanos encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery AT feczkotivadar encapsulationofhumanserumalbumininsubmicrometermagneticpolylactidecoglycolideparticlesasamodelsystemfortargeteddrugdelivery
_version_	1717784908109185024

Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery

Similar Items