Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

Abstract Background Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate...

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Bibliographic Details
Main Authors: Victor Jeger, Mattia Arrigo, Florian F. Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R. Spahn, Dominique Bettex, Alain Rudiger
Format: Article
Language:English
Published: SpringerOpen 2017-04-01
Series:Intensive Care Medicine Experimental
Subjects:
Animal welfare
Analgesia
Nalbuphine
Sepsis
Rat model
Faecal peritonitis
Online Access:http://link.springer.com/article/10.1186/s40635-017-0137-2

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