p85β regulates autophagic degradation of AXL to activate oncogenic signaling
p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.
Bibliographic Details
| Main Authors: |
Ling Rao,
Victor C. Y. Mak,
Yuan Zhou,
Dong Zhang,
Xinran Li,
Chloe C. Y. Fung,
Rakesh Sharma,
Chao Gu,
Yiling Lu,
George L. Tipoe,
Annie N. Y. Cheung,
Gordon B. Mills,
Lydia W. T. Cheung |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-16061-7
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