The main actors involved in extending the invertebrate life span

The main actors involved in extending the invertebrate life span

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Classical invertebrate models, i.e., Drosophila melanogaster and Caenorhabditis elegans, have provided the keys to understand the life span regulation. In the present paper we summarize the mechanisms involved in this process with particular emphasis on the role of the fly fat body. It is interestin...

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Bibliographic Details
Main Authors: E Ottaviani, A Franchini, M Mandrioli
Format: Article
Language:English
Published: University of Modena and Reggio Emilia 2014-02-01
Series:Invertebrate Survival Journal
Subjects:
Drosophila melanogaster; insulin/IGF-1-like pathway; fat body; gut microbiota; longevity
Online Access:http://www.isj.unimo.it/articoli/ISJ323.pdf
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spelling doaj-adbc32b351a74c4e9c32f33f1f2d0d722020-11-25T03:26:55ZengUniversity of Modena and Reggio EmiliaInvertebrate Survival Journal1824-307X2014-02-01117378The main actors involved in extending the invertebrate life spanE Ottaviani0A Franchini1M Mandrioli2Department of Life Sciences, University of Modena and Reggio Emilia, Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, ItalyClassical invertebrate models, i.e., Drosophila melanogaster and Caenorhabditis elegans, have provided the keys to understand the life span regulation. In the present paper we summarize the mechanisms involved in this process with particular emphasis on the role of the fly fat body. It is interesting to note that pathways which lead to an extension of life span are highly conserved in animals so that “longevity pathways” identified in invertebrates provide templates for the identification of genes and drugs that regulate longevity and diseases also in other animals, including mammals.http://www.isj.unimo.it/articoli/ISJ323.pdfDrosophila melanogaster; insulin/IGF-1-like pathway; fat body; gut microbiota; longevity
collection DOAJ
language English
format Article
sources DOAJ
author E Ottaviani
A Franchini
M Mandrioli
spellingShingle E Ottaviani
A Franchini
M Mandrioli
The main actors involved in extending the invertebrate life span
Invertebrate Survival Journal
Drosophila melanogaster; insulin/IGF-1-like pathway; fat body; gut microbiota; longevity
author_facet E Ottaviani
A Franchini
M Mandrioli
author_sort E Ottaviani
title The main actors involved in extending the invertebrate life span
title_short The main actors involved in extending the invertebrate life span
title_full The main actors involved in extending the invertebrate life span
title_fullStr The main actors involved in extending the invertebrate life span
title_full_unstemmed The main actors involved in extending the invertebrate life span
title_sort main actors involved in extending the invertebrate life span
publisher University of Modena and Reggio Emilia
series Invertebrate Survival Journal
issn 1824-307X
publishDate 2014-02-01
description Classical invertebrate models, i.e., Drosophila melanogaster and Caenorhabditis elegans, have provided the keys to understand the life span regulation. In the present paper we summarize the mechanisms involved in this process with particular emphasis on the role of the fly fat body. It is interesting to note that pathways which lead to an extension of life span are highly conserved in animals so that “longevity pathways” identified in invertebrates provide templates for the identification of genes and drugs that regulate longevity and diseases also in other animals, including mammals.
topic Drosophila melanogaster; insulin/IGF-1-like pathway; fat body; gut microbiota; longevity
url http://www.isj.unimo.it/articoli/ISJ323.pdf
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