Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

Objective: Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and calcification in the vascular system in cardi...

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Bibliographic Details
Main Authors: Marsel Lino, David Ngai, Alison Liu, Amanda Mohabeer, Cameron Harper, Laura-lee Caruso, Stephanie A. Schroer, Fred Fu, Trevor McKee, Adria Giacca, Minna Woo, Michelle P. Bendeck
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Metabolism
Subjects:
Obesity
Diabetes
Discoidin domain receptor 1
Collagen
brown fat
Fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300806

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