Genitourinary malformations in neonates conceived by human assisted reproductive technologies

• Main Authors: Marcia de Freitas, Arnaldo Augusto Franco de Siqueira, Conceição Aparecida de Mattos Segre
• Format: Article
• Language: English
• Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2009-12-01
• Series: Einstein (São Paulo)
• Subjects: Congenital abnormalities; Urogenital system; Reproductive techniques; Fertilization in vitro; Sperm injections; intracytoplasmic; Pregnant women
• Online Access: http://apps.einstein.br/revista/arquivos/PDF/1534-Einsteinv7n4p480-4.pdf

Objective: To identify genitourinary malformations among children conceived by assisted reproductive techniques in a population of pregnant women seen at a tertiary hospital in the city of Sao Paulo, Brazil. Methods: A descriptive and retrospective study with data collected from 238 pregnant women who underwent assisted reproduction techniques, including the classic in vitro fertilization and intracytoplasmic sperm injection, and gave birth to 322 children at the Hospital Israelita Albert Einstein. Rresults: The mean maternal age for classic in vitro fertilization was 34 years and for intracytoplasmic sperm injection was 34.8 years. There was an increase in malformed children with older maternal age, but with no statistical significance. Thirty-four malformed newborns were found (10.6%) and 10 (29.4% of malformed children) presented genitourinary malformations. Cconclusions: Several genitourinary malformations were found in children following techniques of human assisted reproduction and there was a tendency to malformation in children as maternal age increased.