CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome

CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome

Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using a murine model for Sjögren's syndrome (SS), we...

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Bibliographic Details
Main Authors: Aya Ushio, Rieko Arakaki, Kunihiro Otsuka, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Keiko Aota, Masayuki Azuma, Naozumi Ishimaru
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
tissue-resident macrophage
chemokine
salivary gland
Sjögren's syndrome
T cell response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02594/full

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