Studying neurodegenerative diseases in culture models

• Main Authors: Johannes C.M. Schlachetzki, Soraya Wilke Saliba, Antonio Carlos Pinheiro de Oliveira
• Format: Article
• Language: English
• Published: Associação Brasileira de Psiquiatria (ABP) 2013-01-01
• Series: Brazilian Journal of Psychiatry
• Subjects: Neurodegenerative diseases; in vitro models; ex vivo models; neurons; neuroglia
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000600005&lng=en&tlng=en

Neurodegenerative diseases are pathological conditions that have an insidious onset and chronic progression. Different models have been established to study these diseases in order to understand their underlying mechanisms and to investigate new therapeutic strategies. Although various in vivo models are currently in use, in vitro models might provide important insights about the pathogenesis of these disorders and represent an interesting approach for the screening of potential pharmacological agents. In the present review, we discuss various in vitro and ex vivo models of neurodegenerative disorders in mammalian cells and tissues.