The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

Sphingosine-1-phosphate (S1P) is generated through phosphorylation of sphingosine by sphingosine kinases (Sphk1 and Sphk2). We show that sphk2 maternal-zygotic mutant zebrafish embryos (sphk2MZ) display early developmental phenotypes, including a delay in epiboly, depleted S1P levels, elevated level...

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Bibliographic Details
Main Authors: Karen Mendelson, Suveg Pandey, Yu Hisano, Frank Carellini, Bhaskar C Das, Timothy Hla, Todd Evans
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
sphingolipids
epiboly
genetics
gastrulation
oogenesis
Online Access:https://elifesciences.org/articles/21992

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