Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL*s⃞

Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL*s⃞

We investigated the in vivo metabolic fate of pre-β HDL particles in human apolipoprotein A-I transgenic (hA-ITg) mice. Pre-β HDL tracers were assembled by incubation of [125I]tyramine cellobiose-labeled apolipoprotein A-I (apoA-I) with HEK293 cells expressing ABCA1. Radiolabeled pre-β HDLs of incre...

Full description

Bibliographic Details
Main Authors: Anny Mulya, Ji-Young Lee, Abraham K. Gebre, Elena Y. Boudyguina, Soon-Kyu Chung, Thomas L. Smith, Perry L. Colvin, Xian-Cheng Jiang, John S. Parks
Format: Article
Language:English
Published: Elsevier 2008-11-01
Series:Journal of Lipid Research
Subjects:
Apolipoprotein A-I
phospholipid transfer protein
lecithin:cholesterol acyltransferase
in vivo catabolism
high density lipoproteins
ABCA1 transporter
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520346162

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520346162

Similar Items