IGF-1 via PI3K/Akt/S6K signaling pathway protects DRG neurons with high glucose-induced toxicity

IGF-1 via PI3K/Akt/S6K signaling pathway protects DRG neurons with high glucose-induced toxicity

Hyperglycemia-induced toxicity of neurons contributes to the pathogenesis and progression of diabetic neuropathy (DNP). High concentration glucose triggered reactive oxygen species (ROS) overproduction and induced cell apoptosis of neurons from dorsal root ganglion (DRG) in vitro. Currently, there i...

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Bibliographic Details
Main Authors: Liu Chunhong, Liu Siyan, Wang Sheng, Sun Yi, Lu Xin, Li Hao, Li Guibao
Format: Article
Language:English
Published: De Gruyter 2019-12-01
Series:Open Life Sciences
Subjects:
high glucose
neurotoxicity
dorsal root ganglion
insulin-like growth factor-1
activating transcription factor 3
Online Access:https://doi.org/10.1515/biol-2019-0056

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