1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features

1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features

Cellular kinases are crucial for the transcription/replication of many negative-strand RNA viruses and might serve as targets for antiviral therapy. In this study, a library comprising 80 kinase inhibitors was screened for antiviral activity against vesicular stomatitis virus (VSV), a prototype memb...

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Bibliographic Details
Main Authors: Sarah Moeschler, Samira Locher, Gert Zimmer
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Viruses
Subjects:
eukaryotic elongation factor 2 kinase
kinase inhibitor
membrane fusion
alkylated imidazolium
ionic liquid
virus entry
enveloped virus
lysosomotropic agent
Online Access:http://www.mdpi.com/1999-4915/10/6/306

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