Effect and mechanism of the CACNA2D1-CGRP pathway in osteoarthritis-induced ongoing pain

Effect and mechanism of the CACNA2D1-CGRP pathway in osteoarthritis-induced ongoing pain

This study built an OA model in rats by monosodium iodoacetate (MIA) injection to determine the effects and mechanism of the voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)-calcitonin gene-related protein (CGRP) pathway in osteoarthritis (OA)-induced ongoing pain. CACNA2D1 expre...

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Bibliographic Details
Main Authors: Liang Sun, Guodong Wang, Meifang He, Zhigang Mei, Fazhou Zhang, Ping Liu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Osteoarthritis
CACNA2D1
CGRP
Dorsal root ganglion
Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220305679

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