Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili

Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-com...

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Main Authors:	Gabriel Waksman, James Lillington
Format:	Article
Language:	English
Published:	MDPI AG 2013-06-01
Series:	Biology
Subjects:	chaperone-usher pathway type I and P pilus chaperone usher donor-strand complementation donor-strand exchange pilicide
Online Access:	http://www.mdpi.com/2079-7737/2/3/841

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spelling	doaj-ad60ad65601647659900bb951177460e2020-11-24T22:03:55ZengMDPI AGBiology2079-77372013-06-012384186010.3390/biology2030841Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P PiliGabriel WaksmanJames LillingtonType I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus biogenesis mechanisms has been exploited to design selective inhibitors of the process.http://www.mdpi.com/2079-7737/2/3/841chaperone-usher pathwaytype I and P piluschaperoneusherdonor-strand complementationdonor-strand exchangepilicide
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gabriel Waksman James Lillington
spellingShingle	Gabriel Waksman James Lillington Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili Biology chaperone-usher pathway type I and P pilus chaperone usher donor-strand complementation donor-strand exchange pilicide
author_facet	Gabriel Waksman James Lillington
author_sort	Gabriel Waksman
title	Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
title_short	Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
title_full	Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
title_fullStr	Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
title_full_unstemmed	Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
title_sort	ordered and ushered; the assembly and translocation of the adhesive type i and p pili
publisher	MDPI AG
series	Biology
issn	2079-7737
publishDate	2013-06-01
description	Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus biogenesis mechanisms has been exploited to design selective inhibitors of the process.
topic	chaperone-usher pathway type I and P pilus chaperone usher donor-strand complementation donor-strand exchange pilicide
url	http://www.mdpi.com/2079-7737/2/3/841
work_keys_str_mv	AT gabrielwaksman orderedandusheredtheassemblyandtranslocationoftheadhesivetypeiandppili AT jameslillington orderedandusheredtheassemblyandtranslocationoftheadhesivetypeiandppili
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Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili

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