Outcome of Critically Ill Patients with Testicular Cancer

• Main Authors: Silvio A. Ñamendys-Silva, Mireya Barragán-Dessavre, Andoreni R. Bautista-Ocampo, Francisco J. García-Guillén, Bertha M. Córdova-Sánchez, Edgar Constantino-Hérnandez, Paulina Correa-García, Octavio González-Chon, Angel Herrera-Gómez
• Format: Article
• Language: English
• Published: Hindawi Limited 2017-01-01
• Series: BioMed Research International
• Online Access: http://dx.doi.org/10.1155/2017/3702605
• ISSN: 2314-6133; 2314-6141

Purpose. To evaluate the clinical characteristics and outcomes of critically ill patients with testicular cancer (TC) admitted to an oncological intensive care unit (ICU). Methods. This was a prospective observational study. There were no interventions. Results. During the study period, 1,402 patients with TC were admitted to the Department of Oncology, and 60 patients (4.3%) were admitted to the ICU. The most common histologic type was nonseminomatous germ cell tumors (55/91.7%). The ICU, hospital, and 6-month mortality rates were 38.3%, 45%, and 63.3%, respectively. The Cox multivariate analysis identified the white blood cells count (HR = 1.06, 95% CI = 1.01–1.11, and P=0.005), ionized calcium (iCa) level (HR = 1.23, 95% CI = 1.01–1.50, and P=0.037), and 2 or more organ failures during the first 24 hours after ICU admission (HR = 3.86, 95% CI = 1.96–7.59, and P<0.001) as independent predictors of death for up to 6 months. Conclusion. The ICU, hospital, and 6-month mortality rates were 38.3%, 45%, and 63.3%, respectively. The factors associated with an increased 6-month mortality rate were white blood cells count, iCa level, and 2 or more organ failures during the first 24 hours after ICU admission.