Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.

Although endosomal compartments have been suggested to play a role in unconventional protein secretion, there is scarce experimental evidence for such involvement. Here we report that recycling endosomes are essential for externalization of cytoplasmic secretory protein tissue transglutaminase (tTG)...

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Bibliographic Details
Main Authors: Evgeny A Zemskov, Irina Mikhailenko, Ru-Ching Hsia, Liubov Zaritskaya, Alexey M Belkin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3083433?pdf=render