Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

Objective: Mice with congenital loss of the glucagon receptor gene (Gcgr−/− mice) remain normoglycemic in insulinopenic conditions, suggesting that unopposed glucagon action is the driving force for hyperglycemia in Type-1 Diabetes Mellitus (T1DM). However, chronic loss of GCGR results in a neomorph...

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Bibliographic Details
Main Authors:	Belen Rivero-Gutierrez, April Haller, Jenna Holland, Emily Yates, Radha Khrisna, Kirk Habegger, Richard Dimarchi, David D'Alessio, Diego Perez-Tilve
Format:	Article
Language:	English
Published:	Elsevier 2018-11-01
Series:	Molecular Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877818306495

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