Management of Trazodone Overdose with Severe Hypotension

Management of Trazodone Overdose with Severe Hypotension

Trazodone is a medication that possesses antidepressant, anxiolytic, and hypnotic properties. Its mechanism of action includes blockade of serotonin type 2 receptors, weak inhibition of serotonin reuptake, blockade of histamine 1 receptors, and blockade of alpha-1-adrenergic receptors. We present a...

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Main Authors: Luis David Camacho, Jack Stearns, Richard Amini
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Case Reports in Emergency Medicine
Online Access:http://dx.doi.org/10.1155/2019/2470592
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spelling doaj-ad3cb70455fb499e8beafcb4bd3b6e5c2020-11-25T00:42:01ZengHindawi LimitedCase Reports in Emergency Medicine2090-648X2090-64982019-01-01201910.1155/2019/24705922470592Management of Trazodone Overdose with Severe HypotensionLuis David Camacho0Jack Stearns1Richard Amini2College of Medicine, University of Arizona, Tucson, AZ, USAThe University of Arizona, Tucson, AZ, USADepartment of Emergency Medicine, University of Arizona, Tucson, AZ, USATrazodone is a medication that possesses antidepressant, anxiolytic, and hypnotic properties. Its mechanism of action includes blockade of serotonin type 2 receptors, weak inhibition of serotonin reuptake, blockade of histamine 1 receptors, and blockade of alpha-1-adrenergic receptors. We present a case of intentional ingestion of an estimated 2500 mg of trazodone leading to persistent hypotension, requiring aggressive fluid resuscitation, pressor support, and intensive care unit admission. Complications associated with trazodone overdoses are significant and clinicians should be aware of the associated symptoms and necessary management plans necessary for such ingestions.http://dx.doi.org/10.1155/2019/2470592
collection DOAJ
language English
format Article
sources DOAJ
author Luis David Camacho
Jack Stearns
Richard Amini
spellingShingle Luis David Camacho
Jack Stearns
Richard Amini
Management of Trazodone Overdose with Severe Hypotension
Case Reports in Emergency Medicine
author_facet Luis David Camacho
Jack Stearns
Richard Amini
author_sort Luis David Camacho
title Management of Trazodone Overdose with Severe Hypotension
title_short Management of Trazodone Overdose with Severe Hypotension
title_full Management of Trazodone Overdose with Severe Hypotension
title_fullStr Management of Trazodone Overdose with Severe Hypotension
title_full_unstemmed Management of Trazodone Overdose with Severe Hypotension
title_sort management of trazodone overdose with severe hypotension
publisher Hindawi Limited
series Case Reports in Emergency Medicine
issn 2090-648X
2090-6498
publishDate 2019-01-01
description Trazodone is a medication that possesses antidepressant, anxiolytic, and hypnotic properties. Its mechanism of action includes blockade of serotonin type 2 receptors, weak inhibition of serotonin reuptake, blockade of histamine 1 receptors, and blockade of alpha-1-adrenergic receptors. We present a case of intentional ingestion of an estimated 2500 mg of trazodone leading to persistent hypotension, requiring aggressive fluid resuscitation, pressor support, and intensive care unit admission. Complications associated with trazodone overdoses are significant and clinicians should be aware of the associated symptoms and necessary management plans necessary for such ingestions.
url http://dx.doi.org/10.1155/2019/2470592
work_keys_str_mv AT luisdavidcamacho managementoftrazodoneoverdosewithseverehypotension
AT jackstearns managementoftrazodoneoverdosewithseverehypotension
AT richardamini managementoftrazodoneoverdosewithseverehypotension
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