In vitro models for the study of Zika virus

• Main Authors: Ekaterina V. Pimenova, Natalya P. Khrapova, Tatyana V. Zamarina
• Format: Article
• Language: Russian
• Published: Central Research Institute for Epidemiology 2020-05-01
• Series: Журнал микробиологии, эпидемиологии и иммунобиологии
• Subjects: zika virus; cell culture systems; model of in vitro
• Online Access: https://microbiol.elpub.ru/jour/article/view/779

Due to the globalization, increased trade and migration flows the probability of outbreaks of Zika fever is significantly increasing worldwide, including Black sea coast of the Caucasus in the Russian Federation. Zika fever tends to spread rapidly and to expand its geography, so the study of this virus remains an urgent task. The accumulated knowledge recently has contributed to a comprehensive study of Zika virus, but so far many questions of etiology, epidemiology, clinic, specific diagnosis and prevention remain unresolved. This review is based mainly on publications by foreign authors and leading international organizations dedicated to the study of Zika virus in the cell lines of various sources . The review summarizes recent experimental data on the use of cell lines as target cells for the study of Zika virus, their advantages and disadvantages, and the susceptibility of different cell lines to this virus. Information from bibliographic and abstract scientific databases, search websites, and publishers: RSCI, Web of Science, Scopus, MEDLINE, Google Scholar, PubMed, Springer Nature, Elsevier, and others was used in the preparation of the review.