Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder

Background: Numerous cognitive and emotional functions are executed asymmetrically between the left and right hemispheres. Right hemisphere hyperactivity/left hemisphere hypoactivity often appears to be a feature in neuroimaging studies of depression. However, few studies have evaluated abnormalitie...

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Main Authors: Zhiwei Zuo, Shuhua Ran, Yao Wang, Chang Li, Qi Han, Qianying Tang, Wei Qu, Haitao Li
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158218303620
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spelling doaj-ad282ff3b78c43148dd197a071c076202020-11-24T21:56:40ZengElsevierNeuroImage: Clinical2213-15822019-01-0121Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorderZhiwei Zuo0Shuhua Ran1Yao Wang2Chang Li3Qi Han4Qianying Tang5Wei Qu6Haitao Li7Department of Radiology, Affiliated Southwest Hospital, Army Medical University, #29 Gaotanyan Main Street, Chongqing 400038, ChinaDepartment of Radiology, Affiliated Southwest Hospital, Army Medical University, #29 Gaotanyan Main Street, Chongqing 400038, ChinaDepartment of Radiology, Affiliated Southwest Hospital, Army Medical University, #29 Gaotanyan Main Street, Chongqing 400038, ChinaDepartment of Radiology, Affiliated Southwest Hospital, Army Medical University, #29 Gaotanyan Main Street, Chongqing 400038, ChinaDepartment of Radiology, Affiliated Southwest Hospital, Army Medical University, #29 Gaotanyan Main Street, Chongqing 400038, ChinaDepartment of Psychology, Affiliated Southwest Hospital, Army Medical University, Chongqing, ChinaDepartment of Psychology, Affiliated Southwest Hospital, Army Medical University, Chongqing, ChinaDepartment of Radiology, Affiliated Southwest Hospital, Army Medical University, #29 Gaotanyan Main Street, Chongqing 400038, China; Corresponding author at: Department of Radiology, Southwest Hospital, #29 Gaotanyan Main Street, Chongqing 400038, China.Background: Numerous cognitive and emotional functions are executed asymmetrically between the left and right hemispheres. Right hemisphere hyperactivity/left hemisphere hypoactivity often appears to be a feature in neuroimaging studies of depression. However, few studies have evaluated abnormalities in structural asymmetry in untreated patients with major depressive disorder (MDD). Methods: In this study, 3-dimensional high-resolution structural magnetic resonance images were acquired from 35 treatment-naïve patients with MDD (mean age = 28.9 years, 22 females) and 35 normal controls. The asymmetry index in cortical thickness and subcortical volume were calculated based on an automated surface-based technique. Results: Abnormalities in structural asymmetry in patients with MDD were mainly located in the cortical-striatal-pallidal-thalamic circuit, including the superior frontal cortex, rostral middle frontal cortex, caudal middle frontal cortex, nucleus accumbens, pallidum and thalamus. No significant correlation was observed between symptom severity and asymmetric measurements. Conclusion: These findings provide further evidence for the altered morphological interhemispheric imbalances in depression and these alterations were independent of depressive symptom severity, suggesting that cerebral asymmetry could be an appropriate indicator of morphological variations in mental disease. Keywords: Major depressive disorder, MRI, Cortical thickness, Subcortical volume, Asymmetryhttp://www.sciencedirect.com/science/article/pii/S2213158218303620
collection DOAJ
language English
format Article
sources DOAJ
author Zhiwei Zuo
Shuhua Ran
Yao Wang
Chang Li
Qi Han
Qianying Tang
Wei Qu
Haitao Li
spellingShingle Zhiwei Zuo
Shuhua Ran
Yao Wang
Chang Li
Qi Han
Qianying Tang
Wei Qu
Haitao Li
Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
NeuroImage: Clinical
author_facet Zhiwei Zuo
Shuhua Ran
Yao Wang
Chang Li
Qi Han
Qianying Tang
Wei Qu
Haitao Li
author_sort Zhiwei Zuo
title Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
title_short Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
title_full Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
title_fullStr Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
title_full_unstemmed Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
title_sort asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
publisher Elsevier
series NeuroImage: Clinical
issn 2213-1582
publishDate 2019-01-01
description Background: Numerous cognitive and emotional functions are executed asymmetrically between the left and right hemispheres. Right hemisphere hyperactivity/left hemisphere hypoactivity often appears to be a feature in neuroimaging studies of depression. However, few studies have evaluated abnormalities in structural asymmetry in untreated patients with major depressive disorder (MDD). Methods: In this study, 3-dimensional high-resolution structural magnetic resonance images were acquired from 35 treatment-naïve patients with MDD (mean age = 28.9 years, 22 females) and 35 normal controls. The asymmetry index in cortical thickness and subcortical volume were calculated based on an automated surface-based technique. Results: Abnormalities in structural asymmetry in patients with MDD were mainly located in the cortical-striatal-pallidal-thalamic circuit, including the superior frontal cortex, rostral middle frontal cortex, caudal middle frontal cortex, nucleus accumbens, pallidum and thalamus. No significant correlation was observed between symptom severity and asymmetric measurements. Conclusion: These findings provide further evidence for the altered morphological interhemispheric imbalances in depression and these alterations were independent of depressive symptom severity, suggesting that cerebral asymmetry could be an appropriate indicator of morphological variations in mental disease. Keywords: Major depressive disorder, MRI, Cortical thickness, Subcortical volume, Asymmetry
url http://www.sciencedirect.com/science/article/pii/S2213158218303620
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