mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11227-4 |
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doaj-ad2327d58d6a49b7a54e496210a1a5f22021-05-11T12:21:25ZengNature Publishing GroupNature Communications2041-17232019-07-0110111610.1038/s41467-019-11227-4mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4Perrine Castets0Nathalie Rion1Marine Théodore2Denis Falcetta3Shuo Lin4Markus Reischl5Franziska Wild6Laurent Guérard7Christopher Eickhorst8Marielle Brockhoff9Maitea Guridi10Chikwendu Ibebunjo11Joseph Cruz12Michael Sinnreich13Rüdiger Rudolf14David J. Glass15Markus A. Rüegg16Biozentrum, University of BaselBiozentrum, University of BaselBiozentrum, University of BaselBiozentrum, University of BaselBiozentrum, University of BaselInstitute for Automation and Applied Informatics, Karlsruhe Institute of TechnologyInstitute of Toxicology and Genetics, Karlsruhe Institute of TechnologyImaging Core Facility, Biozentrum, University of BaselBiozentrum, University of BaselNeuromuscular Center, Departments of Neurology and Biomedicine, University Hospital BaselBiozentrum, University of BaselNovartis Institutes for Biomedical ResearchNovartis Institutes for Biomedical ResearchNeuromuscular Center, Departments of Neurology and Biomedicine, University Hospital BaselInstitute of Toxicology and Genetics, Karlsruhe Institute of TechnologyNovartis Institutes for Biomedical ResearchBiozentrum, University of BaselDenervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injuryhttps://doi.org/10.1038/s41467-019-11227-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Perrine Castets Nathalie Rion Marine Théodore Denis Falcetta Shuo Lin Markus Reischl Franziska Wild Laurent Guérard Christopher Eickhorst Marielle Brockhoff Maitea Guridi Chikwendu Ibebunjo Joseph Cruz Michael Sinnreich Rüdiger Rudolf David J. Glass Markus A. Rüegg |
| spellingShingle |
Perrine Castets Nathalie Rion Marine Théodore Denis Falcetta Shuo Lin Markus Reischl Franziska Wild Laurent Guérard Christopher Eickhorst Marielle Brockhoff Maitea Guridi Chikwendu Ibebunjo Joseph Cruz Michael Sinnreich Rüdiger Rudolf David J. Glass Markus A. Rüegg mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 Nature Communications |
| author_facet |
Perrine Castets Nathalie Rion Marine Théodore Denis Falcetta Shuo Lin Markus Reischl Franziska Wild Laurent Guérard Christopher Eickhorst Marielle Brockhoff Maitea Guridi Chikwendu Ibebunjo Joseph Cruz Michael Sinnreich Rüdiger Rudolf David J. Glass Markus A. Rüegg |
| author_sort |
Perrine Castets |
| title |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_short |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_full |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_fullStr |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_full_unstemmed |
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 |
| title_sort |
mtorc1 and pkb/akt control the muscle response to denervation by regulating autophagy and hdac4 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injury |
| url |
https://doi.org/10.1038/s41467-019-11227-4 |
| work_keys_str_mv |
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| _version_ |
1721444957277913088 |