Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact,...

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Main Authors: Gholam Hossein Farjah, Shadi Salehi, Mohammad Hasan Ansari, Bagher Pourheidar
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2017-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Ischemia
Reperfusion
Spinal cord
Saffron extract
Online Access:http://ijbms.mums.ac.ir/article_8364_b85d5b5c30289647718f2d695bde1869.pdf
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spelling doaj-ad21db0eb80d4c5a9af8de9fe62a1b2e2020-11-25T01:05:12ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742017-03-0120333433710.22038/ijbms.2017.83648364Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in ratsGholam Hossein Farjah0Shadi Salehi1Mohammad Hasan Ansari2Bagher Pourheidar3Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranFaculty of Medicine, Urmia University of Medical Sciences, Urmia, IranDepartment of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranNeurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IranObjective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (Phttp://ijbms.mums.ac.ir/article_8364_b85d5b5c30289647718f2d695bde1869.pdfIschemiaReperfusionSpinal cordSaffron extract
collection DOAJ
language English
format Article
sources DOAJ
author Gholam Hossein Farjah
Shadi Salehi
Mohammad Hasan Ansari
Bagher Pourheidar
spellingShingle Gholam Hossein Farjah
Shadi Salehi
Mohammad Hasan Ansari
Bagher Pourheidar
Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
Iranian Journal of Basic Medical Sciences
Ischemia
Reperfusion
Spinal cord
Saffron extract
author_facet Gholam Hossein Farjah
Shadi Salehi
Mohammad Hasan Ansari
Bagher Pourheidar
author_sort Gholam Hossein Farjah
title Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
title_short Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
title_full Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
title_fullStr Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
title_full_unstemmed Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
title_sort protective effect of crocus sativus l. (saffron) extract on spinal cord ischemia-reperfusion injury in rats
publisher Mashhad University of Medical Sciences
series Iranian Journal of Basic Medical Sciences
issn 2008-3866
2008-3874
publishDate 2017-03-01
description Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P
topic Ischemia
Reperfusion
Spinal cord
Saffron extract
url http://ijbms.mums.ac.ir/article_8364_b85d5b5c30289647718f2d695bde1869.pdf
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AT mohammadhasanansari protectiveeffectofcrocussativuslsaffronextractonspinalcordischemiareperfusioninjuryinrats
AT bagherpourheidar protectiveeffectofcrocussativuslsaffronextractonspinalcordischemiareperfusioninjuryinrats
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