Effect of nonsteroidal anti-inflammatory drugs and tramal on blood pressure level during osteoarthritis treatment in patients with hypertension

• Main Authors: L B Lasebnik, O B Kotsubinskaya, Y V Konev, V N Drosdov
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2004-02-01
• Series: Научно-практическая ревматология
• Subjects: osteoarthritis; nsajd; iruirwl; hypertension
• Online Access: https://rsp.mediar-press.net/rsp/article/view/1232

Objective. To safety of NSAlDs concerning their prohypertensive effect and to devise tactics of management of pts with osteoarthritis and concomitant hypertension. Material and Methods. 98 pts with gonarthrosis and coxarthrosis of stage II-III with pain syndrome and concomitant hypertension of stage 1-II.Diclofenac, ketoprofen, arthrotec and meloxicam were administered. Control group pts received tramal in addition to the treatment. Hypertension was conlrolled with enalapril monotherapy. Results. Groups treated with diclofenac, atrhrotec, meloxicam and ketoprofen showed a tendency to deminution of number of pis with normal decrease of blood pressure (BP) in night hours ("Dipper") and increase of number of pts with insufficient BP nighl fall ("Non-dipper"). These changes may be connected with prohypertensive effect of these drogs. This tendency was more prominent in groups treated with diclofenac and arthrotec. Nimesulid inspite of its marked prohypertensive effect did not impair circadian rhythm of BP. Central analgesic tramal did not possess prohypertensive effect and did not increase BP. Conclusion. According to increase of prohypertensive effect study NSAlDs can be arranged as follows: tramadol, ketoprofen. meloxicam. nimesulid, arthrotec, diclofenac.