Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Abstract Backgrounds/Aim Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Ca2+channel pathway in adult mice left ventricular (LV) apical myocytes at basa...

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Bibliographic Details
Main Authors: Jeremiah Ong’achwa Machuki, Hong-Yuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Li Kexue, Zhiwei Zhao, Hong Sun
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cell Communication and Signaling
Subjects:
Ca2+ transients
Cardiac stress
17β-estradiol
L-type Ca2+ channel
Phosphodiesterase
Sex differences in contractility
Online Access:http://link.springer.com/article/10.1186/s12964-019-0346-2

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http://link.springer.com/article/10.1186/s12964-019-0346-2

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