Tear Film Break-up Time in Bipolar Disorder.

Ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. In psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms. The purpose of this study was to compare tear film stability betwee...

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Main Authors: Parvin Dibajnia, Mohadeseh Mohammadinia, Maryam Moghadasin, Mohammad Aghazade Amiri
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2012-12-01
Series:Iranian Journal of Psychiatry
Subjects:
Online Access:https://ijps.tums.ac.ir/index.php/ijps/article/view/171
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spelling doaj-ad08e8f9e7284f5cb72fe1f91ecfe4342020-11-25T03:01:50ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152012-12-0174Tear Film Break-up Time in Bipolar Disorder.Parvin Dibajnia0Mohadeseh Mohammadinia1Maryam Moghadasin2Mohammad Aghazade Amiri3Shahid Beheshti University of Medical Sciences, Faculty of Rehabilitation Sciences,Tehran, Iran. Ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. In psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms. The purpose of this study was to compare tear film stability between patients who use these drugs with those patients who are not on medication.After obtaining informed consent, the tear film break up time (TBUT) test was performed in 96 eyes of 48 subjects. The subjects were placed in to three groups. Participants included two groups of euthymic bipolar disorder patients (16 cases each) with history of pharmacotherapy for more than two years. Patients in each group were taking only one type of mood stabilizer (lithium carbonate or sodium valproate). In addition,16 age-matched bipolar patients who did not take any topical or systemic medications were included in a control group. Values of TBUT were compared between the three groups using the student's t-test.The mean tear film break up time (TBUT) in test groups were 4.88 seconds± 0.34(lithium group), 4.81 seconds ± 1.60 (valproate group) and 15seconds± 2.0(control group), respectively. No statistically significant differences were observed between the first and the second groups in TBUT values, but significant differences were found between the two groups and the control group (P< 0.0001).The results of this study show that lithium carbonate and sodium valproate contribute to decrease of tear film break up time, resulting from dryness of the eyes.https://ijps.tums.ac.ir/index.php/ijps/article/view/171Bipolar disorderDry eye syndromesLithiumTearsValproic acid
collection DOAJ
language English
format Article
sources DOAJ
author Parvin Dibajnia
Mohadeseh Mohammadinia
Maryam Moghadasin
Mohammad Aghazade Amiri
spellingShingle Parvin Dibajnia
Mohadeseh Mohammadinia
Maryam Moghadasin
Mohammad Aghazade Amiri
Tear Film Break-up Time in Bipolar Disorder.
Iranian Journal of Psychiatry
Bipolar disorder
Dry eye syndromes
Lithium
Tears
Valproic acid
author_facet Parvin Dibajnia
Mohadeseh Mohammadinia
Maryam Moghadasin
Mohammad Aghazade Amiri
author_sort Parvin Dibajnia
title Tear Film Break-up Time in Bipolar Disorder.
title_short Tear Film Break-up Time in Bipolar Disorder.
title_full Tear Film Break-up Time in Bipolar Disorder.
title_fullStr Tear Film Break-up Time in Bipolar Disorder.
title_full_unstemmed Tear Film Break-up Time in Bipolar Disorder.
title_sort tear film break-up time in bipolar disorder.
publisher Tehran University of Medical Sciences
series Iranian Journal of Psychiatry
issn 1735-4587
2008-2215
publishDate 2012-12-01
description Ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. In psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms. The purpose of this study was to compare tear film stability between patients who use these drugs with those patients who are not on medication.After obtaining informed consent, the tear film break up time (TBUT) test was performed in 96 eyes of 48 subjects. The subjects were placed in to three groups. Participants included two groups of euthymic bipolar disorder patients (16 cases each) with history of pharmacotherapy for more than two years. Patients in each group were taking only one type of mood stabilizer (lithium carbonate or sodium valproate). In addition,16 age-matched bipolar patients who did not take any topical or systemic medications were included in a control group. Values of TBUT were compared between the three groups using the student's t-test.The mean tear film break up time (TBUT) in test groups were 4.88 seconds± 0.34(lithium group), 4.81 seconds ± 1.60 (valproate group) and 15seconds± 2.0(control group), respectively. No statistically significant differences were observed between the first and the second groups in TBUT values, but significant differences were found between the two groups and the control group (P< 0.0001).The results of this study show that lithium carbonate and sodium valproate contribute to decrease of tear film break up time, resulting from dryness of the eyes.
topic Bipolar disorder
Dry eye syndromes
Lithium
Tears
Valproic acid
url https://ijps.tums.ac.ir/index.php/ijps/article/view/171
work_keys_str_mv AT parvindibajnia tearfilmbreakuptimeinbipolardisorder
AT mohadesehmohammadinia tearfilmbreakuptimeinbipolardisorder
AT maryammoghadasin tearfilmbreakuptimeinbipolardisorder
AT mohammadaghazadeamiri tearfilmbreakuptimeinbipolardisorder
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