Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are activated in tumor cells. However, the role of this region in...

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Bibliographic Details
Main Authors:	Kashyap Dave, Inderpreet Sur, Jian Yan, Jilin Zhang, Eevi Kaasinen, Fan Zhong, Leander Blaas, Xiaoze Li, Shabnam Kharazi, Charlotte Gustafsson, Ayla De Paepe, Robert Månsson, Jussi Taipale
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-06-01
Series:	eLife
Subjects:	cancer oncogene regulation enhancer
Online Access:	https://elifesciences.org/articles/23382

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