Non-Coding RNAs: Strategy for Viruses’ Offensive

• Main Authors: Alessia Gallo, Matteo Bulati, Vitale Miceli, Nicola Amodio, Pier Giulio Conaldi
• Format: Article
• Language: English
• Published: MDPI AG 2020-09-01
• Series: Non-Coding RNA
• Subjects: immune evasion; miRNA mimicry; viral circRNA; viral non-coding RNA
• Online Access: https://www.mdpi.com/2311-553X/6/3/38

The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.