Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by Bacillus Calmette-Guérin

Mucosal Delivery of Fusion Proteins with Bacillus subtilis Spores Enhances Protection against Tuberculosis by Bacillus Calmette-Guérin

Tuberculosis (TB) is the most deadly infectious disease in existence, and the only available vaccine, Bacillus Calmette-Guérin (BCG), is almost a century old and poorly protective. The immunological complexity of TB, coupled with rising resistance to antimicrobial therapies, necessitates a pipeline...

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Bibliographic Details
Main Authors: Alastair Copland, Gil R. Diogo, Peter Hart, Shane Harris, Andy C. Tran, Mathew J. Paul, Mahavir Singh, Simon M. Cutting, Rajko Reljic
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
spores
vaccine
immunity
adjuvants
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00346/full

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