Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins

Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins

Transport of small molecules across the cell membrane is a crucial biological mechanism for the maintenance of the cell activity. ABC transporter family is a huge group in the transporter membrane proteins and actively transports the substrates using the energy derived from ATP hydrolysis. In humans...

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Bibliographic Details
Main Authors: Mika Sakamoto, Hirofumi Suzuki, Kei Yura
Format: Article
Language:English
Published: The Biophysical Society of Japan 2019-02-01
Series:Biophysics and Physicobiology
Subjects:
coupling helix
differential map
pathogenic variation
pivot-like residue
protein 3d structure
Online Access:https://doi.org/10.2142/biophysico.16.0_68

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