Specifics of cross-aldol condensation of acetaldehyde with formaldehyde in presence of aminoacids and their derivatives

• Main Authors: L. V. Dashko, D. V. Dmitriev, V. R. Flid
• Format: Article
• Language: Russian
• Published: MIREA - Russian Technological University 2009-08-01
• Series: Тонкие химические технологии
• Subjects: acid-base catalysis, aldol-croton condensation, homo-condensation of acetaldehyde, cross condensation of acetaldehyde with formaldehyde, catalysis by aminoacids, catalysis by aminoacid derivatives
• Online Access: https://www.finechem-mirea.ru/jour/article/view/1079

Reaction of cross-aldol condensation of acetaldehyde with formaldehyde at presence of aminoacids and their ether- and benzoil-derivatives were studied in pyridine, N, N-dymethylacetamide, water and toluene. It was shown that aminoacids are capable to catalyse cross- and homocondensation of acetaldehyde. The yield of acrolein in presence of aminoacids is much lower than with use of its derivatives. The selectivity of cross-condensation is dependent from acid-base properties of catalyst and the reaction media. It is found that the main contribute to catalysis of cross-condensation is introduced by amino-group of aminoacid and it basic properties determine the yield of acrolein