Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials

Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials

Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this revi...

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Main Authors: Benedetta Russo, Fabiana Picconi, Ilaria Malandrucco, Simona Frontoni
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
metabolic syndrome
insulin-resistance
flavonoids
Online Access:https://www.mdpi.com/1422-0067/20/9/2061
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spelling doaj-ace53b863dce462ea61ccc5caf9cbef92020-11-24T22:05:44ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-04-01209206110.3390/ijms20092061ijms20092061Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical TrialsBenedetta Russo0Fabiana Picconi1Ilaria Malandrucco2Simona Frontoni3Unit of Endocrinology, Diabetes and Metabolism, S.Giovanni Calibita, Fatebenefratelli Hospital, 00186 Rome, ItalyUnit of Endocrinology, Diabetes and Metabolism, S.Giovanni Calibita, Fatebenefratelli Hospital, 00186 Rome, ItalyUnit of Endocrinology, Diabetes and Metabolism, S.Giovanni Calibita, Fatebenefratelli Hospital, 00186 Rome, ItalyUnit of Endocrinology, Diabetes and Metabolism, S.Giovanni Calibita, Fatebenefratelli Hospital, 00186 Rome, ItalyInsulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling.https://www.mdpi.com/1422-0067/20/9/2061metabolic syndromeinsulin-resistanceflavonoids
collection DOAJ
language English
format Article
sources DOAJ
author Benedetta Russo
Fabiana Picconi
Ilaria Malandrucco
Simona Frontoni
spellingShingle Benedetta Russo
Fabiana Picconi
Ilaria Malandrucco
Simona Frontoni
Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
International Journal of Molecular Sciences
metabolic syndrome
insulin-resistance
flavonoids
author_facet Benedetta Russo
Fabiana Picconi
Ilaria Malandrucco
Simona Frontoni
author_sort Benedetta Russo
title Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_short Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_full Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_fullStr Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_full_unstemmed Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
title_sort flavonoids and insulin-resistance: from molecular evidences to clinical trials
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-04-01
description Insulin-resistance is one of the main factors responsible for the onset and progression of Metabolic Syndrome (MetS). Among all polyphenols, the effects of flavonoids and their main food sources on insulin sensitivity have been widely evaluated in molecular and clinical studies. The aim of this review is to analyse the data observed in vitro, in vivo and in clinical trials concerning the effects of flavonoids on insulin resistance and to determine the molecular mechanisms with which flavonoids interact with insulin signaling.
topic metabolic syndrome
insulin-resistance
flavonoids
url https://www.mdpi.com/1422-0067/20/9/2061
work_keys_str_mv AT benedettarusso flavonoidsandinsulinresistancefrommolecularevidencestoclinicaltrials
AT fabianapicconi flavonoidsandinsulinresistancefrommolecularevidencestoclinicaltrials
AT ilariamalandrucco flavonoidsandinsulinresistancefrommolecularevidencestoclinicaltrials
AT simonafrontoni flavonoidsandinsulinresistancefrommolecularevidencestoclinicaltrials
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