A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Summary: Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report that the DNA demethylase TET3 is anom...

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Bibliographic Details
Main Authors: Yetao Xu, Xiaoli Sun, Ruling Zhang, Tiefeng Cao, Shi-Ying Cai, James L. Boyer, Xuchen Zhang, Da Li, Yingqun Huang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719317577

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