Molecular karyotyping of human single sperm by array- comparative genomic hybridization.

Molecular karyotyping of human single sperm by array- comparative genomic hybridization.

No valid method is currently available to analyze the entire genome of sperm, including aneuploidies and structural chromosomal alterations. Here we describe the optimization and application of array-Comparative Genomic Hybridization (aCGH) on single human sperm. The aCGH procedure involves screenin...

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Bibliographic Details
Main Authors: Cristina Patassini, Andrea Garolla, Alberto Bottacin, Massimo Menegazzo, Elena Speltra, Carlo Foresta, Alberto Ferlin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3614952?pdf=render

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