Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells.

Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells.

Assessing the cytoplasmic uptake of fluorescently-tagged drugs in heterogeneous cell types currently involves time-consuming manual segmentation of confocal microscopy images. We developed a set of methods that incorporate map algebra techniques to facilitate and expedite image segmentation, particu...

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Bibliographic Details
Main Authors: Allan Kachelmeier, Tsering Shola, William B Meier, Anastasiya Johnson, Meiyan Jiang, Peter S Steyger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6211712?pdf=render

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