Oxidative Stress in Patients With Acne Vulgaris
Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as cata...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.380 |
| Summary: | Acne vulgaris is one of the common dermatological
diseases and its pathogenesis is multifactorial. In this study, we
aim to determine the effects of oxidative stress in acne vulgaris.
Forty-three consecutive acne
patients and 46 controls were enrolled. The parameters of
oxidative stress such as catalase (CAT), glucose-6-phosphate
dehydrogenase (G6PD), superoxide dismutase (SOD), and
malondialdehyde (MDA) in the venous blood of cases were measured
spectrophotometrically. The values compared with control group,
the relation between the severity and distribution of acne, and
the correlation of each enzyme level were researched.
CAT and G6PD levels in patients were found to be
statistically decreased, and SOD and MDA levels were found to be
statistically increased (P<.001). However, any statistical
difference and correlation could not be found between the severity
and distribution of lesions and the mean levels of enzymes. In
addition, we found that each enzyme is correlated with one another.
Our findings show that oxidative stress
exists in the acne patients. It will be useful to apply at least
one antioxidant featured drug along with the combined acne
treatment. |
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| ISSN: | 0962-9351 1466-1861 |