PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading
Bone loss occuring with unloading is associated with decreased osteoblastogenesis and increased bone marrow adipogenesis, resulting in bone loss and decreased bone formation. Here, we review the present knowledge on the role of PPARγ in the control of osteoblastogenesis and bone mass in skeletal unl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2006-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/PPAR/2006/64807 |
| Summary: | Bone loss occuring with unloading is associated with decreased
osteoblastogenesis and increased bone marrow adipogenesis, resulting in bone loss and decreased bone formation. Here, we review the present knowledge on the role of
PPARγ in the control of osteoblastogenesis and bone mass in skeletal unloading. We
showed that PPARγ positively promotes adipogenesis and negatively regulates
osteoblast differentiation of bone marrow stromal cells in unloading, resulting in bone
loss. Manipulation of PPARγ2 expression by exogenous TGF-β2 inhibits the
exaggerated adipogenesis and corrects the balance between osteoblastogenesis
and adipogenesis induced by unloading, leading to prevention of bone loss. This
shows that PPARγ plays an important role in the control of bone mass in unloaded
bone. Moreover, this opens the possibility that manipulation of PPARγ may correct
the balance between osteoblastogenesis and adipogenesis and prevent bone loss,
which may have potential implications in the treatment of bone loss in clinical
conditions. |
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| ISSN: | 1687-4757 1687-4765 |