Inhibition of hepatitis B virus and induction of hepatoma cell apoptosis by ASGPR-directed delivery of shRNAs.

Inhibition of hepatitis B virus and induction of hepatoma cell apoptosis by ASGPR-directed delivery of shRNAs.

Hepatitis B virus (HBV) infection is a worldwide liver disease and nearly 25% of chronic HBV infections terminate in hepatocellular carcinoma (HCC). Currently, there is no effective therapy to inhibit HBV replication and to eliminate hepatoma cells, making it highly desired to develop novel therapie...

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Bibliographic Details
Main Authors: Jingwei Ma, Chunmei Huang, Xinxin Yao, Chuan Shi, Lifang Sun, Lu Yuan, Ping Lei, Huifen Zhu, Hongbo Liu, Xiongwen Wu, Qin Ning, Chun Zhou, Guanxin Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3477153?pdf=render

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