Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain

Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain

Abstract Background Calcitonin gene-related peptide (CGRP) as a mediator of microglial activation at the transcriptional level may facilitate nociceptive signaling. Trimethylation of H3 lysine 27 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that regulates inflammatory-relat...

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Bibliographic Details
Main Authors: Qi An, Chenyan Sun, Ruidi Li, Shuhui Chen, Xinpei Gu, Shuhong An, Zhaojin Wang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Neuroinflammation
Subjects:
Calcitonin gene-related peptide
Microglia
Histone H3 lysine 27 trimethylation
Neuropathic pain
ChIP-sequencing
Online Access:https://doi.org/10.1186/s12974-021-02168-1

Internet

https://doi.org/10.1186/s12974-021-02168-1

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