Interactions between cationic liposomes and an antigenic protein: the physical chemistry of the immunoadjuvant action

The 18 kDa antigenic protein from Mycobacterium leprae (P) or its N-acyl derivative (AP) was incorporated in dioctadecyldimethylammonium bromide (DODAB) liposomes in water or in phosphate-buffered saline (PBS). In water, 100﹪ P incorporation in liposomes contrasts with 65﹪ in PBS. There is 75-80﹪ AP...

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Bibliographic Details
Main Authors: L R Tsuruta, W Quintilio, M H Costa, A M Carmona-Ribeiro
Format: Article
Language:English
Published: Elsevier 1997-10-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520371315