| Summary: | Bystander selection has been shown to result in strong population-level correlations between the level of antimicrobial consumption in the general population and resistance to that antimicrobial or similar antimicrobials in a range of bacteria. The prevalence of clarithromycin resistance in Helicobacter pylori has been increasing rapidly resulting in increased difficulty to eradicate this infection. Using country- and WHO-world-region-level macrolide resistance data from a systematic review and macrolide consumption data from the MIDAS Quantum data base, we tested the hypothesis that the prevalence of clarithromycin resistance was correlated with macrolide consumption. At a country level, we found these variables to be positively correlated (Spearman’s rho = 0.49; P = 0.007). Whilst positive, the correlation between macrolide consumption and primary resistance was not statistically significant at world region level (Spearman’s rho = 0.95; P = 0.05). Keywords: H. pylori, Macrolide, Antimicrobial resistance, Ecological study
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