Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy

• Main Authors: Dimakatso R. Mokoena, Blassan P. George, Heidi Abrahamse
• Format: Article
• Language: English
• Published: MDPI AG 2019-09-01
• Series: International Journal of Molecular Sciences
• Subjects: photodynamic therapy (pdt); gold nanoparticle (aunp); cannabidiol (cbd); breast cancer therapy
• Online Access: https://www.mdpi.com/1422-0067/20/19/4771

Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over the past decades, it is acceptable to admit that these are expensive, invasive, associated with many side effects and, therefore, a reduced quality of life. One of the most possible solutions to this could be the use of gold nanoparticle (AuNP) conjugated photodynamic therapy (PDT) in combination with cannabidiol (CBD), a <i>Cannabis</i> derivative from the <i>Cannabis sativa</i>. Since the use of <i>Cannabis</i> has always been associated with recreation and psychoactive qualities, the positive effects of <i>Cannabis</i> or its derivatives on cancer treatment have been misunderstood and hence misinterpreted. On the other hand, AuNP-PDT is the most favoured form of treatment for cancer, due to its augmented specificity and minimal risk of side effects compared to conventional treatments. However, its use requires the consideration of several physical, biologic, pharmacologic and immunological factors, which may hinder its effectiveness if not taken into consideration. In this review, the role of gold nanoparticle mediated PDT combined with CBD treatment on breast cancer cells will be deliberated.