Characterization of a Novel Mitochondrial Ascorbate Transporter From Rat Liver and Potato Mitochondria

Characterization of a Novel Mitochondrial Ascorbate Transporter From Rat Liver and Potato Mitochondria

The Mitochondrial Ascorbic Acid Transporter (MAT) from both rat liver and potato mitochondria has been reconstituted in proteoliposomes. The protein has a molecular mass in the range of 28–35 kDa and catalyzes saturable, temperature and pH dependent, unidirectional ascorbic acid transport. The trans...

Full description

Bibliographic Details
Main Authors:	Vito Scalera, Nicola Giangregorio, Silvana De Leonardis, Lara Console, Emanuele Salvatore Carulli, Annamaria Tonazzi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Series:	Frontiers in Molecular Biosciences
Subjects:	ascorbic acid mitochondria transport liposomes reconstitution plants
Online Access:	https://www.frontiersin.org/article/10.3389/fmolb.2018.00058/full

Similar Items

The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs
by: Annamaria Tonazzi, et al.
Published: (2021-03-01)

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics
by: Annamaria Tonazzi, et al.
Published: (2013-09-01)

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury
by: Lara Console, et al.
Published: (2020-07-01)

Carnitine Traffic in Cells. Link With Cancer
by: Lara Console, et al.
Published: (2020-09-01)

Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology
by: Nicola Giangregorio, et al.
Published: (2020-02-01)

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane
by: Yifan Ge, et al.
Published: (2020-01-01)

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice Through Modulation of Mitochondrial Respiration
by: Yunseon Jang, et al.
Published: (2020-03-01)

Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders
by: Serrano G, et al.
Published: (2015-12-01)

Influence of exogenous ascorbic acid and glutathione priming on mitochondrial structural and functional systems to alleviate aging damage in oat seeds
by: Fangshan Xia, et al.
Published: (2020-03-01)

Interactive Software for the study of membrane biology: lipid composition, solubilization and liposome reconstitution and characterization
by: I.A. Borin, et al.
Published: (2006-07-01)

Integrin-Functionalised Giant Unilamellar Vesicles via Gel-Assisted Formation: Good Practices and Pitfalls
by: Mariem Souissi, et al.
Published: (2021-06-01)

Important amino acid residues of potato plant uncoupling protein (StUCP)
by: P. Jezek, et al.
Published: (2000-12-01)

Antitumor Effect of Hyperoside Loaded in Charge Reversed and Mitochondria-Targeted Liposomes
by: Feng Y, et al.
Published: (2021-04-01)

Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective
by: Zhenjie Wang, et al.
Published: (2017-11-01)

Assessment of the nutritional safety of new potatoes imported to Poland using an ascorbate-nitrate index
by: Wadas Wanda, et al.
Published: (2018-09-01)

Molecular mechanism of inhibition of the mitochondrial carnitine/acylcarnitine transporter by omeprazole revealed by proteoliposome assay, mutagenesis and bioinformatics.
by: Annamaria Tonazzi, et al.
Published: (2013-01-01)

Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
by: Luz M. Medrano, et al.
Published: (2018-12-01)

An Overview of the Antioxidant Effects of Ascorbic Acid and Alpha Lipoic Acid (in Liposomal Forms) as Adjuvant in Cancer Treatment
by: Mohamed Attia, et al.
Published: (2020-04-01)

Membrane-anchored human Rab GTPases directly mediate membrane tethering in vitro
by: Naoki Tamura, et al.
Published: (2014-10-01)

The function of ascorbate oxidase in Arabidopsis thaliana
by: Lim, Choon Kiat
Published: (2012)

Topical Application of Trisodium Ascorbyl 6-Palmitate 2-Phosphate Actively Supplies Ascorbate to Skin Cells in an Ascorbate Transporter-Independent Manner
by: Shuichi Shibuya, et al.
Published: (2017-06-01)

X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system
by: Xuefan Gu, et al.
Published: (2020-06-01)

Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments
by: Una Janke, et al.
Published: (2021-06-01)

THE EFFECTS OF Na-ASCORBATE ON ASCORBATE CONCENTRATION IN THE PLASMA AND TISSUES
by: Zoran Pavlovic, et al.
Published: (2003-10-01)

Scientific Opinion on the re‐evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives
by: EFSA Panel on Food additives and Nutrient Sources added to Food (ANS)
Published: (2015-05-01)

Ascorbate Oxidase-Based Amperometric Biosensor for L-Ascorbic Acid Determination in Beverages
by: Péter Fűtő, et al.
Published: (2016-01-01)

A novel role for fatty acid transport protein 1 in the regulation of tricarboxylic acid cycle and mitochondrial function in 3T3-L1 adipocytes
by: Brian M. Wiczer, et al.
Published: (2009-12-01)

Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats
by: Azadeh Khalili, et al.
Published: (2020-01-01)

Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction
by: Liao C, et al.
Published: (2018-07-01)

Learning and Memory Impairment Induced by the Injection of Ascorbic Acid and Ascorbate Oxidase into the Hippocampus in the Morris Water Maze
by: sh Jamali, et al.
Published: (2015-04-01)

CHANGES IN THE ANTIOXIDANT CAPACITY OF POTATOES DEPENDING ON THE CULTIVAR, CONTENTS OF POLYPHENOLS, CHLOROGENIC ACID AND ASCORBIC ACID
by: Janette Musilova, et al.
Published: (2015-02-01)

Transcriptomic analysis reveals the metabolic mechanism of L-ascorbic acid in Ziziphus jujuba Mill.
by: Chunmei eZhang, et al.
Published: (2016-02-01)

Determination of Ascorbic Acid, Total Ascorbic Acid, and Dehydroascorbic Acid in Bee Pollen Using Hydrophilic Interaction Liquid Chromatography-Ultraviolet Detection
by: Meifei Zhu, et al.
Published: (2020-12-01)

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd
by: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Published: (2013-02-01)

Genetic Control of Ascorbic Acid Biosynthesis and Recycling in Horticultural Crops
by: Ifigeneia Mellidou, et al.
Published: (2017-07-01)

The biochemical consequences of ascorbate deficiency in Arabidopsis thaliana
by: Sultana, Nighat
Published: (2011)

Conclusion on the peer review of the pesticide risk assessment of the active substance L-ascorbic acid
by: European Food Safety Authority
Published: (2013-04-01)

ASCORBIC ACID MODULATES SPONTANEOUS THYMOCYTE APOPTOSIS
by: Goran Ranković, et al.
Published: (2005-12-01)

The use of ascorbic acid as a food additive: technical-legal issues
by: Michele Varvara, et al.
Published: (2016-02-01)

An Ascorbate Bluetooth© Analyzer for Quality Control of Fresh-Cut Parsley Supply Chain
by: Ylenia Spissu, et al.
Published: (2021-09-01)