Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway

Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and accumulating evidence indicates that the AMPK-mTOR signaling pathway regulates the activation of the autophagy pathway through the coordinated phosphorylation of ULK1. In this study, we investigated the mechanisms u...

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Bibliographic Details
Main Authors: Jin-Feng Wang, Zhi-Gang Mei, Yang Fu, Song-Bai Yang, Shi-Zhong Zhang, Wei-Feng Huang, Li Xiong, Hua-Jun Zhou, Wei Tao, Zhi-Tao Feng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; puerarin; autophagy; cerebral ischemia/reperfusion; AMPK-mTOR-ULK1 signaling pathway; light chain 3; p62; ischemic stroke; AMPK/mTOR; traditional Chinese medicine; middle cerebral artery occlusion; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=6;spage=989;epage=998;aulast=Wang

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